Name Emtricitabine
Classes Antiinfective Agent
Antiviral Agent
NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Diseases HIV
Viral Infection

Emtricitabine

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) that works by blocking the reverse transcriptase enzyme, which is required by the virus to replicate. By blocking the replication of the virus, emtricitabine helps to decrease the amount of virus in the body, leading to a reduction in the symptoms of HIV infection.

 

Emtricitabine is indicated for the treatment of HIV infection.

 

Emtricitabine may be taken without regard to food. 

Adult Patients (18 years of age and older) 

  • Emtricitabine capsules: one 200 mg capsule administered once daily orally. 
  • Emtricitabine oral solution:  240 mg (24 mL) administered once daily orally.

Pediatric Patients (0–3 months of age) (2.3): 

  • Emtricitabine oral solution:  3 mg/kg administered once daily orally.

Pediatric Patients (3 months through 17 years): 

  • Emtricitabine oral solution:  6 mg/kg up to a maximum of 240 mg (24 mL) administered once daily orally.
  • Emtricitabine capsules: for children weighing more than 33 kg who can swallow an intact capsule, one 200 mg capsule administered once daily orally.

Dosage modification is required for patients with renal impairment.

 

Most common adverse reactions are-

  • headache
  • diarrhea
  • nausea
  • fatigue
  • dizziness
  • depression
  • insomnia
  • abnormal dreams
  • rash
  • abdominal pain
  • asthenia
  • increased cough
  • rhinitis.
  • Skin hyperpigmentation (very common in pediatric patients)

 

  • Emtricitabine can cause liver problems, and patients with liver disease should use this medication with caution.
  • It may also cause lactic acidosis, a rare but serious condition that can lead to death.
  • Emtricitabine may interact with other medications, including some anti-seizure medications, antibiotics, and anti-fungal medications. Patients should inform their doctor about all medications they are taking before starting treatment with emtricitabine.

 

Contraindication

Emtricitabine is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the products.