Neomycin Sulphate + Polymixin B Sulphate + Prednisolone is indicated for the following conditions-

• Eye infections
• Conjunctivitis
• Uveitis
• Eye inflammation (due to chemical/mechanical injury)

Eye Infection

Conjunctivitis

Eye inflammation

1–2 drops in the conjunctival sac (s). Drops may be used hourly in severe disease, tapering to discontinuation as the inflammation declines. Drops can be used up to four to six times per day for mild disease. In the beginning, no more than 20 mL should be prescribed, and the prescription should not be refilled without further evaluation.

1. Eye Drop	Eye Drops
2. Eye ointment	Eye Ointment

Adverse reactions to corticosteroid/anti-infective combination drugs have occurred, which can be attributed to the corticosteroid component, the anti-infective component, or the combination. Exact incidence figures are unavailable due to a lack of a denominator of treated patients.

• Ocular hypertension
• Glaucoma
• Optic nerve damage
• Cataract
• Delayed wound healing

Occular hypertension

Glaucoma

Cataract

• The initial prescription and renewal of the medication order beyond 20 mL of Neomycin Sulphate + Polymyxin B Sulphate + Prednisolone should be made by a physician only after a thorough examination of the patient using magnification, such as slit lamp bio-microscopy and, if necessary, fluorescein staining.
• If the patient's signs and symptoms do not improve after two days, he or she should be reevaluated.
• Because fungal infections of the cornea are more likely to develop concurrently with long-term corticosteroid use, fungal invasion should be suspected in any persistent corneal ulceration where a corticosteroid has been used or is being used.
• When necessary, fungal cultures should be obtained.
• IOP should be monitored if this product is used for more than 10 days.
• Prolonged use of topical anti-bacterial agents may give rise to overgrowth of non-susceptible organisms including fungi.
• If the inflammation or pain lasts more than 48 hours or worsens, the patient should be advised to stop taking the medication and consult a doctor.