Dydrogesterone is indicated for the following conditions-

• Symptomatic relief of mild to moderate vasomotor symptoms associated with menopause.
• Prevention of postmenopausal osteoporosis
• Dysmenorrhoea
• Endometriosis
• Secondary amenorrhoea
• Irregular menstrual cycles
• Uterine bleeding

Menopause	Post Menopausal Osteoporosis (Brittle Bone)	Dysmenorrhea
Endometriosis	Irregular Menstrual Period	Uterine Bleeding

• Relief of mild to moderate vasomotor symptoms associated with menopause/prevention of postmenopausal osteoporosis/Continuous Sequential Therapy: An estrogen is administered continuously, and a 10 mg dydrogesterone tablet is added for the final 14 days of each 28-day cycle in a sequential manner.
• Cyclic Therapy: When estrogen is administered cyclically with a treatment-free interval, typically 21 days on and 7 days off, one 10 mg dydrogesterone tablet is added for the last 12-14 days of estrogen therapy.
• Dysmenorrhea: 10 mg taken twice daily from day 5 to day 25 of the menstrual cycle.
• Endometriosis: 10 mg two or three times daily from day 5 to day 25 of the cycle or continuously.
• Stopping Dysfunctional Bleeding: 10 mg taken twice daily for five to seven days. Dydrogesterone should be administered with estrogen.
• Prevention of Dysfunctional Bleeding: 10 mg taken twice daily from day 11 to day 25 of the cycle. Dydrogesterone should be given with estrogen.
• Amenorrhea: Administer estrogen once daily from day 1 to day 25 of the cycle, along with 10 mg dydrogesterone taken twice daily from day 11 to day 25 of the cycle.
• Irregular Cycles: 10 mg taken twice daily from day 11 to day 25 of the cycle.
• Threatened Miscarriage: Administer 40 mg at once, followed by 10 mg every eight hours until symptoms remit.

Common side effects associated with dydrogesterone include-

• Headache
• Breast Pain or Tenderness
• Nausea
• Fatigue
• Mood Changes

Headache

Breast Tenderness

Nausea

Fatigue

• Thromboembolic Disorders: Use with caution in individuals with a history of thromboembolic disorders.
• Breast Cancer: Evaluate risks and benefits in patients with a history of breast cancer.
• Liver Function: Monitor liver function in patients with pre-existing liver disease.
• Pregnancy and Lactation: Dydrogesterone is contraindicated during pregnancy and lactation.