| Name | Doripenem |
| Classes |
Antiinfective Agent Antibiotic Carbapenem |
| Diseases |
Infectious Disease UTI (Urinary Tract Infection) |
Bangla
EnglishDoripenem
Doripenem is a carbapenem class antibiotic used to treat complex intra-abdominal and urinary tract infections. It kills bacteria by inhibiting synthesis of bacterial cell wall. It is a broad spectrum antibiotic.
Doripenem is used to treat the following diseases-
- Complicated Intra-Abdominal Infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus and Peptostreptococcus micros.
- Complicated Urinary Tract Infections, Including Pyelonephritis caused by susceptible strains of pathogens.
Doripenem is administered as intravenous infusion. For complicated abdominal infection, the recommended dose is 500mg/8hrs for 5-14 days. For complicated UTI including polynephritis, the usual dose is 500mg/8hrs for up to 10 days.
Doripenem can cause side effects like anaphylaxis & serious hypersensitivity. It can also cause seizures. Inhalational use of doripenem can cause pneumonitis.
Severe hypersensitivity & anaphylactic reactions have been reported with Doripenem use. Seizures have also been reported. Doripenem can cause Clostridium difficile Associated Diarrhea. Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of C. difficile. Due to a drug interaction, patients with seizure disorders controlled with valproic acid or sodium valproate will be at an increased risk for breakthrough seizures when treated with Doripenem concomitantly.
Contraindication
Doripenem is contraindicated in people who are hypersensitive to Doripenem or any other drugs of the beta lactam class.
There is no known interaction of doripenem with food and drinks.
There is no known health conditions where doripenem is contraindicated.