Disopyramide is indicated for the treatment of:

• Ventricular arrhythmias, including ventricular tachycardia and ventricular fibrillation.
• Supraventricular arrhythmias, including atrial fibrillation and atrial flutter, particularly when accompanied by congestive heart failure.

Arrhythmia

Ventricular Tachycardia

Ventricular fibrillation

• Take 300 mg to 800 mg daily, divided into separate doses.
• For older individuals, it is advisable to decrease the dosage considering diminished renal and hepatic function, particularly in elderly non-smokers.

Common side effects of disopyramide include-

• Dry mouth
• Blurred vision
• Urinary retention
• Constipation
• Nausea/vomiting
• Dizziness

Dry Mouth

Blurred vision

Nausea

Constipation

• Proarrhythmic Effects: Disopyramide can exacerbate existing arrhythmias or precipitate new arrhythmias, particularly in patients with structural heart disease. Monitor cardiac rhythm closely during therapy.
• Anticholinergic Effects: Use caution in patients with glaucoma, urinary retention, or gastrointestinal obstruction, as disopyramide's anticholinergic effects can worsen these conditions.
• QT Prolongation: Disopyramide may prolong the QT interval, increasing the risk of torsades de pointes and other ventricular arrhythmias, especially at higher doses or in patients with electrolyte abnormalities.
• Hepatic Impairment: Use with caution in patients with hepatic impairment, as disopyramide is primarily metabolized in the liver. Dosage adjustments may be necessary.
• Pregnancy and Lactation: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Disopyramide may be excreted in breast milk; breastfeeding should be avoided during treatment.
• Given the recognized proarrhythmic characteristics of disopyramide and the absence of proof indicating enhanced survival with any antiarrhythmic medication in patients lacking life-threatening arrhythmias, the utilization of disopyramide and other antiarrhythmic agents should be restricted to individuals experiencing life-threatening ventricular arrhythmias.