| Name | Dinoprost |
| Classes |
Uterotonic Agent |
| Diseases |
Pregnancy |
Bangla
EnglishDinoprost
Dinoprost is a synthetic analogue of the naturally occurring prostaglandin F2 alpha. Dinoprost appears to act directly on the myometrium, but this is not proven. Dinoprost stimulates myometrial contractions in the gravid uterus that are similar to the contractions that occur in the term uterus during labor (via its interaction with prostaglandin receptors). These contractions are usually enough to induce abortion. Throughout pregnancy, the uterine response to prostaglandins gradually increases. Dinoprost can also help with cervical dilatation and softening.
- Dinoprost should only be given by trained obstetricians in a hospital setting with adequate obstetrical care facilities.
- Because prostaglandins enhance the effect of oxytocin, Dinoprost must be discontinued before oxytocin administration begins, and the patient's uterine activity must be closely monitored for uterine hyperstimulation. If uterine hyperstimulation occurs or labor begins, the vaginal insert should be removed. Dinoprost should also be removed before performing an amniotomy.
- Dinoprost is contraindicated when prolonged uterine contractions may jeopardize fetal safety and uterine integrity. Dinoprost should not be given to patients who have had a previous cesarean section or uterine surgery because of the risk of uterine rupture and associated obstetrical complications.
- Dinoprost should be used with caution in women with ruptured membranes, cases of non-vertex or non-singleton presentation, and patients with a history of previous uterine hypertony, glaucoma, or a history of childhood asthma, even if there have been no asthma attacks in adulthood.
- When the Dinoprost vaginal insert is in place, uterine activity, fetal status, and the progression of cervical dilatation and effacement should be closely monitored. Any signs of uterine hyperstimulation, sustained uterine contractions, fetal distress, or other fetal or maternal adverse reactions should prompt the removal of the insert.