Alendronic Acid is indicated for the treatment of-

• Osteoporosis in post-menopausal women
• Osteoporosis in men and women
• Treatment of glucocorticoid-induced osteoporosis
• Treatment of Paget's disease of bone

Osteoporosis (Brittle Bone)

Paget's Disease

• Treatment of osteoporosis in postmenopausal women and in men: 10 mg daily or 70 mg (tablet or oral solution) once weekly.
• Prevention of osteoporosis in postmenopausal women: 5 mg daily or 35 mg once weekly.
• Glucocorticoid-induced osteoporosis: 5 mg daily; or 10 mg daily in postmenopausal women not receiving estrogen. 
• Paget's disease: 40 mg daily for six months.

Instruct patients to:

• Swallow tablets whole with 6-8 ounces plain water at least 30 minutes before the first food, drink, or medication of the day.
• Swallow oral solution followed by at least 2 ounces of water.
• Not lie down for at least 30 minutes after taking Alendronic acid and until after food.

Most common adverse reactions for alendronate are:

• abdominal pain
• acidity
• constipation
• diarrhea
• dyspepsia
• musculoskeletal pain
• nausea

Abdominal Pain	Acidity	Constipation
Diarrhea	Dyspepsia	Myalgia

• Upper Gastrointestinal Adverse Reactions can occur. Instruct patients to follow dosing instructions. Discontinue if new or worsening symptoms occur.
• Hypocalcemia can worsen and must be corrected prior to use.
• Severe Bone, Joint, Muscle Pain may occur. Discontinue use if severe symptoms develop.
• Osteonecrosis of the Jaw has been reported.
• Atypical Femur Fractures have been reported. Patients with new thigh or groin pain should be evaluated to rule out an incomplete femoral fracture.