Agomelatine is indicated for the treatment of major depressive episodes in adults. It is used to alleviate symptoms associated with major depressive disorder, including mood disturbances, sleep disturbances, and changes in appetite or weight.

Depression

Sleeping Disorder

Inappetite

• The recommended starting dose is 25 mg once daily at bedtime, which can be increased to 50 mg if necessary.
• The maximum recommended dose is 50 mg daily.

Adverse reactions associated with the use of agomelatine include-

• Headache
• Dizziness
• Insomnia
• Somnolence
• Nausea
• Diarrhea
• Fatigue
• Anxiety
• Abdominal pain
• Back pain

Headache	Dizziness	Insomnia (Difficulty in Falling asleep)
Somnolence	Nausea	Anxiety

• Suicidal Ideation and Behavior: Monitor patients for the emergence of suicidal thoughts and behaviors, especially during the early treatment period or when there are dosage adjustments. Advise families and caregivers to be vigilant.
• Liver Function: Assess liver function before initiating treatment and regularly during therapy, especially in patients with pre-existing hepatic conditions. Discontinue treatment if significant liver abnormalities occur.
• Serotonin Syndrome: Caution is advised when co-administering Agomelatine with other serotonergic drugs. Monitor for symptoms of serotonin syndrome, such as agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, or loss of coordination.
• Hypomania/Mania: Monitor for signs of hypomania or mania, especially in patients with a history of bipolar disorder.
• Use in Elderly: Use caution in elderly patients, as they may be more sensitive to the effects of Agomelatine.
• Withdrawal Symptoms: Discontinuation of Agomelatine should be done gradually to reduce the risk of withdrawal symptoms.