Drospirenone + Ethinylestradiol is an estrogen/progestin COC, indicated for use by women to: 

• Prevent pregnancy. 
• Treat symptoms of premenstrual dysphoric disorder (PMDD) for women who choose to use an oral contraceptive for contraception. 
• Treat moderate acne for women at least 14 years old only if the patient desires an oral contraceptive for birth control.

Prevention of Pregnancy

Premenstrual Dysphoric Disorder (PMDD)

Acne

• Take one tablet daily by mouth at the same time every day. 
• Tablets must be taken in the order directed on the blister pack.

The most common adverse reactions associated with Drospirenone and Ethinylestradiol use include:

• headache
• migraine
• menstrual irregularities 
• nausea
• vomiting
• breast pain/tenderness 
• mood changes 

Headache

Migraine

Menstrual Disorder

Breast Tenderness

• Cigarette smoking increases the risk of serious cardiovascular events (blood clots, heart attacks, and strokes) associated with Drospirenone and Ethinylestradiol use, especially in women over 35 years of age.
• The medication should not be used in women with a history of blood clots, stroke, heart attack, or liver disease.
• Women with a history of breast cancer or other estrogen- or progestin-sensitive cancers should not use this medication.
• Drospirenone and Ethinylestradiol may increase potassium levels in the blood, which can cause serious heart problems in women with kidney, liver, or adrenal gland problems.
• The medication may cause changes in lipid and glucose metabolism and should be used with caution in women with diabetes or high cholesterol.
• Women should be advised to use additional contraception during the first 7 days of treatment, as the medication may not be immediately effective in preventing pregnancy.
• If the patient misses a dose, she should take it as soon as possible and use a backup method of contraception for the next 7 days.
• The medication should not be taken during pregnancy or while breastfeeding.